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That's intended. Struggling makes you more in control.
Youre more able to do things like resist getting undressed and resist position changes. While being better at undressing enemies and forcing positions on them.
How much the difficulty increases depends on how angry the enemy becomes. More angry enemies hurt you more often.

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I personally collected a bunch of manticore spikes and kept stabbing her with them. After that its a matter of staying alive long enough while the aphrodesiac does its work.