I'm using 2020.3.12f1, but I worked it out. It was an issue with how Mac unzips packages for unity. This discussion shows what was happening:
https://answers.unity.com/questions/1473305/how-to-import-a-unitypackage-from-wi...
I'm still trying to work out my issues with slight blurring between pixels, but it's largely due to attempting to use sprite renderer to show pixel art with a 3D camera. I'm trying to avoid using textures on quads to animate. Thank you for your help :)