When I got to campaign mode, I felt kind of disappointed that you start from 0 every time you beat a scenario. I felt like I wasn't "building up a run" over the course of multiple games, like I'd imagine a good tower climb roguelike would do, but that the only influence my previous floors had was unlocking relics (too chance-based to be meaningful).
I see some obvious logistics problems with this: Fear and status effects would probably build up too fast, there should be a dice face unlocked after beating the final scenario to deal with this, or maybe just a lot more abilities that interact with status effects (imagine an ability whose cost is in status effected die)
Experience would build up too fast, so getting all 4 dice blocks in the first scenario (which is basically guaranteed) would give such a huge advantage that could carry you through the whole game, maybe the levels should be paced out more, there could be a lot more levels in between the dice unlocks (that could add a lot more interesting rewards, maybe legendary faces or artifacts or relics, obviously some of those would be too OP to get on a level up so you can use your imagination)
I see a good tower-climbing campaign as the "definitive version" of this game, so I hope it can become more than just streaking through all of the scenarios and re-unlocking the relics you already have. The old one could still stay as a separate mode, because it would probably be harder than a continuous run ever could be, but a good continuous mode (the chaos realm doesn't cut it for me, personally, some of the encounters in the scenario are so well-designed that randomness actually ruins their difficulty, making it impossible to lose, or impossible to win) would add a lot more replayability to this game for me.