Er, to be honest it took some fiddling. I tried again just now, and it seems this works:
- Install a recent version of Wineskin (https://github.com/Gcenx/WineskinServer#how-to-install)
- Run Wineskin, and create a new app wrapper (picking any wine 64bit engine should work)
- Open the newly wrapper created in /Users/your_username/Applications/, it will prompt you to install the target software
- Pick "Copy a directory", and select the uncompressed LADX-HD directory (containing the exe file) you just downloaded
- Then choose to run "Winetricks", check "app/.NET 6.0 Desktop Runtime" and "settings/renderer=gl", and click "Run"
- Once everything is installed, close the app, and then re-open it from the Finder.
- The game should launch 🤞