1. Deleted the folder you said.
2. Launching Mannequin via Itch.
3. I create a new file, everything works, the window is loaded.
4. Restart Mannequin.
5. I create a new file, everything works again, the window is loaded.
6. Save the character's test file.
7. Restart Mannequin.
8. I select a character file, and try to change the pose, clothes, etc. and again I get to the endless loading of the window.
It seems to me that this is a problem in the save files, when reading the file, an error may occur somewhere in the program code, check it.
I can give you a save file if you need it.