It's not a 100% guaranteed possibility like with earlier easier versions. Never heal up unless you've depleted your health pool. Minotaurs always guard a chest. And chests are always guarded by minotaurs. Guardians are 1 per qudrant. Use that info when calculating exploration risk, but don't forget the 9HP and 11HP oddities. Level up instead of healing whenever you can. THE VERY MOMENT you hit 10HP, take out the bomb lich and score another easy level up. Look for the 8x8x8 pattern of the slime wizard and deep strike on his butt (You can blind jump into a square). Learn the ? gazers patterns and they can similarly be nuked from orbit with pinpoint precision. Try not to waste HP on walls until the very last sweep and remember you can kill the dragon for 13G without ending the run which comes in handy on that very last cleanup pass. Play cleverly and take every advantage of the numbers. I can pull it off maybe 30% of the time.