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It works in wine

turn on windows compatibility mode set to 8.1 and make sure you have the dch GPU drivers for some reason this game hates running with studio/non dch drivers

likely not unless nami remakes it in a dif version of RPG maker afaik this is in VX Ace Which has no MacOS support someone may have made a MacOS RTP which would let Mac Players play it

if you have a newer mac you could try using wine (compatibility layer to run windows stuff on Linux and unix OSes like MacOS or BSD) it should work decently well since MacOS is in the BSD family and I played it on another BSD family OS using wine