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I haven’t tried many origins myself, but I’ve read the descriptions, so I know what they do. In most cases, the debuffs outweigh the benefits. And “Bimbo” just really bothers me; I get the concept, but it disables certain abilities by reducing intelligence.

Due to the effects and dialogue, other origins come across with a sort of odd personality. But Gamine’s dialogue feels more like, “I’m doing this because I need to survive, not because I enjoy it.” and it fits more with the storyline if you pick former man origin. 

I've restarted the game 3 times and I found a talk with Emile will show you the best origin perk, which is Gamine.