I had this issue maybe, do you mean mouse highlights stuff it's not on? Or cursor won't show up at all in game?
If the former, while in the menu that works for you, go settings, video, turn off auto resolution then lower the screen resolution by one or two manually. Say down to 1280x800 if that works, in game raise it one at a time till it won't again then go back to main and lower it once, remember to apply after each change.
Or just leave it the first time it works.
Good luck