The spices accessory is ok on occasion but you definitely don't need 3 or to keep them long term. The health rings are trash items, opt to get health max from the priests and fountains instead. With the extra space, go for more damage scaling accessories or weapons, or energy boosts.
I've been trying to get an ethereal sword + bomb run going but have not seen the staff on about 20 tries. I think the numbers need to be tuned a bit to make this game more fun as it is a really, really low % chance to get any non standard run going.
Didn't get a single permanent energy relic or gem, or the assassin hood :(
Finally ran out of consumables as well. The queen's cleaver in the centre spot has +4 rage generation per use from smithing upgrades. Initial damage is 634, each attack adds 456 additional damage.
I found a strange bug / interaction with the pickaxe: If you have vampirism and regular damage on the weapon and kill an enemy with the vampirism (dmg activates first) then it gives you two gems.