Twice now, after finishing dialogue with a character, Karla will be completely stuck in place. Additionally, I will be unable to go to the menu or interact with a character despite being in range (the first time this happened the prompt showed up, but the second time there was no prompt). I've also had some issues getting the dialogue option buttons to work but ultimately they will if I just click them a few times.
I see that a lot of these are issues that other people have reported, but I myself have not been able to find any workaround or solution to the game locking up like this, aside from having to completely restart it.