• I decided to attack the kobold instead of pay the exorbitant sum for a bracelet.  Now I have the Rebels' hideout as a permanent quest location with no associated actions.  I seem to recall text suggesting I come back later, but I tried that after a few days and nothing.
• I didn't have enough money to pay for Cali when I first encountered the slavers.  I figured I could sell a few resources at the market and come back, but the button is gone and there is another quest location I can neither forget nor interact with.
• I failed to convince Anastasia to join me, so I went in search of the mind control.
  • At one point, I answered "No" when that was the only option and there didn't seem to be a question directed at me.
  • When I then visited Anastasia, I was surprised to find that I could not employ said mind control.  By reading the code, I now know that this is because we had already had a discussion, but (1) I'm not sure why that should be, and (2) it was not at all obvious to me.  I ended up playing through an entire week of game time hoping that something would change before deciding to dig into the logic myself.  This put off me being able to move into Act 2.

Hope that helps