In the pause menu I can't access settings at all.
When ever my character is facing left I have trouble attacking. Maybe 1 click in 10 will register as an attack
For the life of me I can't figure out how to use spells. I see a fireball down in the bottom right corner, but clicking on it does nothing, and I've hit every button on the keyboard and mouse.

A few of these are genuine problems but you need to hold down the spell to activate it, tapping it just cycles your spells

Just figured I'd add my own experiences here since the thread exists, a lot of level creation and out of bounds bugs dealing with knockback (via spartan armor and done by like the snake enemies) as well as secret rooms. A couple of times when I wasn't knocked out of the map the explosion from opening the secret room has knocked the character model out of order until I either reset the run or managed to get to the next floor. sometimes the secret room itself will not register properly with the floor plan and when you go into the hallway entry for it you just drop out of the map. When using the spartan armor high attack speed weapons are un-usable for boss fights because of the knockback the armor gives being able to knock them over the walls of the room.