I'm sure some of you will already have done this, but I give this suggestion to those that are maybe feeling a little too familiar with the game.
There are probably plenty of people who are purposefully avoiding certain things and deciding their own fate.
I put it to you, to let fate decide.
Introduce a dice and roll based on your decisions, much like a game of D&D. This in turn will help you make for an adventure you may not otherwise experience and It'll develop a character as you make choices. Maybe you won't be so bold to challenge and attempt to top things, for fear of becoming the bottom.
The most important thing is to live with the fate that has been decided. If you decide to do something, and the dice say you fail, live with that.
Don't reload saves to get your way. I would say if you want to go properly hardcore with this idea, don't save at all, unless you're session needs to be placed on hold. (Attempt to, where possible, end your session while camping/resting)
Let me know what you think of this idea, and I'd love to hear any stories that end up developing from this. Have fun ;)