I have some HTML5 games I'm working on porting to Itch and making sure they work in the Itch app. They use <a> links for things like unintrusive self-promo, crediting authors of used resources, getting the source code if it's open-source, etc. Presently, those links open in the game window, which is very suboptimal - the user ought to have access to their bookmarks/logins/etc.
I've tried target="_blank" on both <base> and <a>, as well as window.open; they're all no-ops. Ideally the app should detect links to http(s):// URLs and open them in the default browser. Until then, I'll intercept clicks on them, copy their URLs to the clipboard, and tell the player "go paste in your web browser".