I tried with compatibility options but beside flashing a window, tha game won't start
The only thing I can think of, make sure you are running the pc version and not the mac version. If that is not it, please try describing your issue with the term "Ren'Py" into google. Haremwatch uses this engine, which is used by many other games to run. It is a universal game engine, so perhaps your error has been solved by others.