I'm not sure at what point it happens, but there seems to be a certain amount of progression that invariably corrupts my save files. I'll usually play for extended periods of time before saving and quitting, so it's hard to nail down when it happens, but I'll try loading up a file of a game I've spent a lot of time playing and itll give the me the following console error message and then the game gets stuck trying to load.

MissingMethodException: Method not found: 'Default constructor not found...ctor() of SHand'