Its possible there may be a bigger issue here, so I'm gonna say my issue: 
I use a controller as a mouse, so when I play the game, the only way to select --say the options menu
I need to alt+tab out of the game, with the game still visible, I select options menu to highlight it,
then click the "A button" on my controller to access the menu.
No matter what I click on in game normally, it won't access. 

Also, if I hover the mouse over a menu item, it'll highlight for a sec, but only once. 
So if I move my mouse over every menu selection, and across them again, they won't highlight. 
Which again, I can't actually select/access any of the menu options without tabbing out, clicking on them from outside the game, 
and then hitting "A button" to open that item. 
This is also applies in-game, when I want to select a scene or interact with her. I haft to do this to play.

I use Xpadder w/ HidHide