First I want to thank you from the bottom of my heart for implementing this! It is a marvelous piece of software and I really appreciate it!
Now the good news, the program runs perfectly fine in Mac with M3 processor using Whisky (I think Crossover should work as well).
The only thing needed is to install Whisky, download the marvel-lcg zip, unzip it and copy it to the C: of the "Bottle".
Then run marvel-lcg.exe and connect through the browser as in Windows.
Except saving a game and then continuing it I was able to play perfectly fine with a custom deck donwloaded from marvelcdb.