• Launching Nuclear Throne with NTT mod opens with a black screen.
• Can still hear game audio, can hear myself clicking around the menu.
• Played update NTT 9883 with friends in the past, that worked fine.
• Played NTT 9885 with friends in the past, that worked fine. Issue came up within the last month.
• Uninstalling mod (including re-installing the base game on steam) allows the base game to run fine.
• Tried installing a previous NTT build, still have the issue.

Try updating your drivers and restarting your computer. If the problem still persists, scream as loud as you can and I'll try to find you.

EDIT: Also try hitting alt+enter to exit fullscreen mode.