Top rated featured Puzzleon sale with Mouse support (15 results)
Explore Puzzle games with Mouse support on itch.io. Games that challenge the player with critical thinking to solve levels. · Sell your games with Mouse support on itch.io to have them show up here.
New itch.io is now on YouTube!
Subscribe for game recommendations, clips, and more
SpaceChem is an obscenely addictive, design-based puzzle game about fake science!
Puzzle
Boot up your Z5 Powerlance and dial into Last Call BBS, the last game from Zachtronics!
Puzzle
Use the MOLEK-SYNTEZ to create small molecules with various pharmacological effects.
Puzzle
Build factories that assemble products for your alien overlords, and try not to die in the process.
Puzzle
Master the intricate, physical machinery of the transmutation engine— the alchemical engineer’s most advanced tool!
Puzzle
Add up, multiply, clone, and divide your party members to beat the monsters on your path!
Puzzle
The year is 1997. You used to be a hacker, but now you have the phage.
Puzzle
