Seems It's blocks on right IP address
$ curl -v https://itch.io
* Trying 45.33.107.166:443...
* connect to 45.33.107.166 port 443 failed: Connection refused
* Failed to connect to itch.io port 443 after 318 ms: Couldn't connect to server
* Closing connection 0
curl: (7) Failed to connect to itch.io port 443 after 318 ms: Couldn't connect to server