Since itch has a worldwide audience, this is an interesting question. And what is considered sensitive is subject to a lot of subjectivity and local bias.
The tricky part is, to know, if you have to check that box. Especially for simple nudity. Or in the continuum between a jump scare and gore horror to set the line between made for adults only and being ok for "kids".
So I would check four things.
1. Is my target audience 13+ or 18+?
2. Will facebook mums get outraged, if their 13yo kids play your game?
3. Are similar popular games on itch marked as sensitive or not?
4. Would a streamer get in trouble for broadcasting gameplay of your game on the major platforms?
Especially 3. should give a good answer, since most stuff here is "correctly" marked.