There is a feature in Unity (and I'm sure can be implemented anywhere else) where you pixelate the output of the camera rather than using pixelated sprites. This means you don't have to worry at all about consistently sized pixels, and the sprites themselves can even be drawn! Although the output might look odd in places where sprites rotate it would probably still look more consistent than randomly sized pixels?
For context I've only ever played one autobattler a LONG time ago, but I still don't think a deep comprehensive tutorial is necessary. If the UI gets cleaned up, I feel even people who haven't played this genre before will get it.