I agree that any easy method to exclude any single tag would be very appreciated. Multiple exclusions would be even better, but just having the ability to remove one or not show things again would be a great thing to have.
Viewing post in Actual working tag exclusion
While this will not help on mobile, the itch app, or if you can't use browser extensions, I did make some tools for that.
A box to enter and apply persistently the known exclude query string. (unpacked Chrome extension)
Buttons for the genres to exclude any of them. (tampermonkey script)
Ignore/Highlight function for games/developers on the press of a button (tampermoney script)
Oh, and this exlucde query string method only works, if you are logged in.