While this will not help on mobile, the itch app, or if you can't use browser extensions, I did make some tools for that.
A box to enter and apply persistently the known exclude query string. (unpacked Chrome extension)
Buttons for the genres to exclude any of them. (tampermonkey script)
Ignore/Highlight function for games/developers on the press of a button (tampermoney script)
Oh, and this exlucde query string method only works, if you are logged in.