I don't have any experience running SynthNes on wine, but you'll probably need to set up serial over USB for it. Here are some random links that I found that might help
https://askubuntu.com/questions/1083286/using-usb-serial-adapter-with-wine
I don't have any experience running SynthNes on wine, but you'll probably need to set up serial over USB for it. Here are some random links that I found that might help
https://askubuntu.com/questions/1083286/using-usb-serial-adapter-with-wine