In the second level of a run, one of the red orbs was out and able to be destroyed normally, but the second one (along with all of its enemies) was stuck outside the level's intended barriers, I guess? I could still shoot the enemies if I was careful, and they could still hurt me if I brushed against them, but I was totally soft-locked and couldn't progress in the run anymore. This is the first and only time this has happened so far in a few dozen runs, just for clarity's sake.
