As funny as that is, I actually see (and write) Mezz as one of those weird people who can down stuff like that, get a solid benefit from it, but never really get the jitters for some inexplicable reason. A freak of nature. And though that extreme may be unrealistic, caffeine sensitivity is a real thing: there are people devastated by half a cup of coffee, and others that have to drink mind-breaking amounts just to get a decent buzz going. Variation in body chemistry I guess. Though you'd think Mezz would be on the sensitive side given his size and lack of body mass. Maybe it's a bunny thing.
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I heard about people with ADHD being more resistant to stimulants, which is also something I experience as an ADHD patient. Caffeine and nicotine only make me feel focused, not buzzed, which I heard is a common trait we have; I quit smoking and vaping, to clarify. I'm not saying you intend for Mezz to have ADHD, it just reminded me of that.
Funny enough, depressants are the exact opposite for me, making me feel absolutely terrified. The only depressant I could handle was alcohol, although I quit that, too. Don't quote me on the pharmacological aspects relating to any of this, I'm not an expert. I also have autism, which may or may not affect how I react to some drugs, I really have no clue.
This talk of stimulants made me think of something interesting, though I'll share it privately, for whenever you have the time to read it.
The way caffeine works is weird. It's less that it makes you energetic and more it slots into the receptors in your brain for another chemical that tells it that you're tired. The brain adapts so it makes more receptors so you have to consume more caffeine for the same effects. Mezz could have built a tolerance over time.
Oh believe me, I know about tolerance. I'm talking about something a little different though: the way the body responds, even completely fresh to a given substance, long before any tolerance has had time to build up. Personally, I'm kind of both: I'm VERY sensitive to caffeine, to the point that going in fresh after months away produces an almost euphoric effect, far beyond what most people describe. But on the other hand, while tolerance does build eventually and repeated use ends up negatively impacting my mood, even on a fresh exposure I'm never really "jittery" like some people describe, twitching and shaking, feeling like the world's closing in on me etc. There are a lot of people that basically give themselves panic attacks if they have any significant amount, and I've never felt even remotely like that. The worst caffeine has ever done to me is like how Bilbo described the effect of the One Ring: like butter spread over too much bread.