im not sure what issue you have but for me lut loved to remove the exctubable line, so check the configuration tab on your file. Make sure its set, as for the game use touch screen or set up a custom mapping.
under configure use the runner wine download the package by selecting it on the left hand table, if you haven't already.
Next,
dubble check your executable is navigated in your configuration for the file, game options tab.
for me my nav is: /home/deck/downloads/emu/WIN/WIN.H/TalesOfAndrogny.exe
yours may be different if you have your files less organized but for me i have a bunch of files, mods ect. So i have a bit more of a linear and o.c.d file set up. Your should look if default as, home/deck/downloads/Tales Of Androgyny win64[osdesegnation, im using 64bit.] My runner tab is usung default