This is a cool project! Mom's knife from Isaac was always one of my favorite weapons. I don't like the fact you are so slow tho, I can't seem to dodge attacks easily. The pixel art and the powerups in the crafting system are really nice, but I found it hard to understand how the crafting works. I kept clicking and got something, but I couldn't recreate it. The way the potion worked was really good tho.
There seems to be a crazy amount of polish in some areas, and too little in others. Still, a really cool game, nice job :)