I think the problems occur when you export games from game engines as browser games. But you can also develop games specifically for browsers (without game engines) and split the graphics into many small files so that the graphics are only loaded when needed and therefore quickly.
But I don't want to complain here, because I'm glad that I was able to upload my game to Itch. It's just a shame that I probably won't be able to update it before it reaches a size of 50mb.
My statement should only serve as information about what you should consider with Itch for larger browser games.