Interesting little game, although it could use some touching up in the UX department.
A lot of the initial gameplay doesn't necessarily make sense right off the bat; it took me a while to figure out how to even open up shop. A quick tutorial would be really helpful - one other specific thing I wanted to mention is that it isn't super clear that the timer is for completion of the day, rather than a "complete the customer's order before this time or they get mad" sort of timer.
I really liked the sound effects, though, and the core idea behind the gameplay loop seems solid - making potions to get coins to unlock ingredients to make potions that get you more coins.
As for art, since you specifically mentioned wanting feedback on it - the potion and ingredient sprites look solid, as does most of the shop (there's a few spots like where the crack in the floor meets the wall where it looks a bit weird, but those are largely passable.) The customers feel a little bit odd, though - them being in black&white with sketch outlines while the rest of the game is fully-textured color makes them feel a bit out of place.
Overall, great work, and I look forward to seeing where this goes!