Thanks :]
Apple really doesn't make dev life easier. They pretty much abandoned OpenGL years ago and now want to get rid of it completely in favor of their proprietary API. Now they get rid of 32 bit support and do some silly useless "notarisation" shenannigans. I hadn't heard about the WINE issues, but it seems to be due to the missing 32 bit support.
My guess would be, if you want to support OSX, that the AGS SDL2 port is your best bet.