My experience and what I've seen.
If you want to sell on Itch, you need to advertise the game outside of Itch.
On PC, it is very, very frowned upon to have ADS and your game will possibly be rated poorly.
On the web it is more common, but if you look, almost no one on Itch uses them, so again, if you add ADS it is possible that your game will be ignored by many players.
On Android it is much more common and people are usually used to that, however, due to permission issues many people will prefer the game to be on the Google Play Store.
The problem is not how much work you have put into the game, the problem is that the world of video games is oversaturated with games and it gets worse every day, if you do not have a solid marketing strategy or if you do not have a community that supports you, it does not matter the price, you will sell nothing.