Sounds like it might be your antivirus or Windows Defender doing sketchy shit. It happens with a lot of games these days. It may have quarantined a file that you need to restore, or you might need to run the game as an Administrator. If you cant fix the issue, delete the game and redownload, watching the screen after you install to see if Windows does anything weird. These steps usually fix whatever issues a game has unless the issue is with the game itself, and mine runs fine.. ^_^ But by the sound of it, it sounds like your computer is denying you access to the file location. So it sounds like an administrative permission thing. I hate today's computer issues, telling me what I can and cannot do on my own damn machine.. -_-; You have both my advice and my sympathies, bro