A recommendation I think would be good is if the requirements for an action were displayed when hovering over an option. It can get pretty frustrating to have all of your options suddenly get grayed out for no apparent reason.
Viewing post in Amelia's Stranded Adventure comments
This is a bit more difficult than it sounds to implement if we're talking about all buttons. Only thing I can think of that would grey out all buttons would be having Amelia not sleep for 25+ hours.
Do you remember which buttons or where Amelia was when this happened to you? I can probably allow main buttons to be pressed while sending a diary saying it failed instead, though I don't know how helpful that would be and if it might just clutter and confuse what's going on.