Virus programs are notorious for giving false positives, and they also often cause slow-down and other issues. At this point, especially if you're not using the stuff built into Windows, you're probably doing more harm than good. The days of viruses that would overwrite your files with gibberish or corrupt your boot sector or whatever are long in the past anyway; now days it's mostly about hijacking your system to use as a bot in DDoS attacks or maybe ransomewaring you. But the best antivirus is just common sense. If you're downloading something from a shady website, probably good to toss it through a few scans. If you're downloading a game from a creator on Itch with three titles under the belt, 99% chance it's fine.
If you're not willing to uninstall, check your antivirus's documentation and figure out how to set exceptions so it will leave the game alone.