Step 1: Move the game (.app) to the Desktop.
Step 2: Open the terminal and paste this "cd ~/Desktop/Karlson_mac.app/Contents/MacOS/", then press enter (don't use cmd+v, right click and select paste).
Step 3: Now type "chmod +x Karlson", then press enter.
Step 4: Now type "./Karlson" (this will try to open the file, but since it's an executable downloaded from the Internet, macOS will complain, and a window will pop up, press "Cancel").
Step 5: Now open System Settings (press `cmd + space` or however you want to open it, click Security & Privacy, and make sure to be in the "General" Tab. On the bottom of the window a "Open Anyway" button should be present, click it.
Step 6: Now a new confirmation window will pop up, press "Open"
Now the Unity configuration window will open, choose your configuration
Finally press "Play!" and the game will successfully start
From now on simply double clicking on the .app file will make the game run.