There's a gamebreaking bug that will spawn rooms that can't be exited. Three times now I've had it happen, all in different rooms. It seems to have a chance to happen in any room that doesn't have hostile NPCs in it.
I see! how late does that it occur? like rough estimate on how many rooms in, and does it happen after the Boiler room? when you get a new form.
Each time it happened I had visited the boiler room 3+ times without enough teeth. I had the white heart transformation.