What arguably kills most adult in-dev games is a big change like this. Since your game operates on a patch to patch model, it is functionally an Early Access title. When Early Access games don't see significant game-play development for a prolonged time people will inevitable abandon them. Reviewing a lot of the comments you can tell this is the direction your followers are going; Most of the comments are asking you to maintain only the Renpy version or even both versions of the game (Which is unrealistic), with this exact hesitation in mind. It's not impossible, the Carnal Instinct team has managed to make it work while they update to Unreal 5, but you'll absolutely see a significant drop in support and possibly even receive threatening messages.
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The first part is what essentially has me playing around with the idea in the first place. The game hasn't received a substantial update in a prolonged period of time, and a lot of dev time has been spent turning Renpy into something it's not.
So far on my discord and patreon as well a lot of people have been for the change.
One advantage that MonXXX has for the change i beleive is the fact that GDScript runs extremely similar to Python, which Renpy and a majority of MonXXX's code is written in. Which should make transferring the project a bit easier than others.
Taking significant time to release fundamentally the exact same content you have now with minimal new in-game content, really seems to antagonize people, especially entitled Patreon supporters. Case in point, Summertime Sagas 'Tech' update and Breeders of the Nephelyms 'UI' update. If you feel you can continue to work on your game despite those kinds of people you'll do fine though.