So this fatal error is something that happens on amd systems. Also if you can please email in your crash logs.
1. If you could share your hardware specification it would help with further debugging
2. Try lowering video settings
3. Try different window modes
4. If using any resource intensive software in background, try closing them
5. If using undervolt on GPU, try using stock settings
6. Try removing all files in C:\Users\USER\AppData\Local\SapphireSafari\Saved\Config and C:\Users\USER\AppData\Local\SapphireSafari\Saved\SaveGames\Settings
7. You could try using DDU (Display Driver Uninstaller) to remove GPU drivers and install them fresh
Let me know how you get on.