What was your money like when it broke for you, and what room/s did you fight in?
When hoarding large sums of coins (+100k/+500k/+1mil) on the day market re-stocks, enemy level skyrockets (up to the 1000s when you have 1mil+). Seemed to me that a big level gap between invader & defender breaks combat somehow, though not with regard to the to-hit chances, but damage. Seems there's a level multiplier in play in the background; and with that at work, when you pit a lvl ~1000 invader vs a lvl 50 defender, defender attacks will deal about 0-2 points dmg, while the invader dude can basically one-shot you with a jab.
I did notice that such high-level invaders will also play all their combat anims in one go & REAL fast, only so far it didn't break my game like it did yours. May also be that itz putting too much load on your rig in that situation, thus freezing & breaking combat - this game hogs more RAM/VRAM than CP2077 on all ultra, judging by the speed of my RTXs cooler fan^^.
And there was one other thread that discussed combat being broken/bugged, but only in certain rooms, though much like you described I think: Freezing OR not being able to target invader, thus unable to win without gadgets. So maybe change the room interior on your defender's spot, see if that helps any. And avoid hoarding loads of coin on re-stock day, take note of invader lvl, if big lvl gap is the issue maybe. No other ideas on this topic, sry.