I'm usually pretty good at quick time events, but i failed the 4 hit combo a lot which felt extremely punishing. Less damage, less ap charge, and the combo goes down next turn. In the Slay the Spire formula, taking any extra damage is extremely punishing. The QTE's could be made easier or clearer, but I'd personally love to see them replaced by something with more thematic relevance and that doesn't pose as much of an accessibility hurdle.
Maybe an out there suggestion, but smaller health pools that regenerate between fights might capture the feeling of a fighting game better, where it's okay to take risks as long as you maintain an edge of skill over your opponent.
One thing that bothered me a lot was going through the pause menu to set skills, which paused the music. It makes setting skills feel like changing a setting rather than a gameplay mechanic