I've seen this game in a lot of previous DDs but only just got around to it. It's great! I'll echo what others said in that it's very difficult and while I can appreciate how much went into making different combinations of mixtures, it feels like only the single mixes are worth it, though maybe that's me not experimenting with them.
It also would be nice to have a reminder that you can upgrade your weapons- my best run I accidentally had enough to buy 5 at once.
Are you going to add bosses? It feels a little cheap that the goal is only to find the floor portal.
And the shopkeeper needs to get mad if you hit her.