not sure if it is really a problem, but in later stages of the game (at least on realistic) if you do a craving event and get 2k Kilo the game will take about 10-30 minutes counting up your fat points.
Similarly if you constantly get new girls (cutting fans in half) it becomes hard to pay for both food and Bed upgrades.
Right now these are not a problem as they tend to happen around the final 5 stages of growth, but if we are to fill that room it could be a time consuming endeavor to wait for fat points and money to accumulate.