Hello there!
By the screen mockup, it looks more like a 2D point and click game for me.
I'm working on some template projects, which can be repurposed/reskinned (sidescroller, isometric, grid based, arpg combat, topdown, point and click, etc. , some minigames, and some systems, like inventory, shops, dialogs, etc.), and I think one of my half done templates looks very much like what you want to do with this game.
I'm planning to finish my current game on this week, after that I can continue working on the templates... if I start with picking up that one, it will probably be in a presentable state on the next week.
I have over 10 years of professional experience with .net/C#, but started gamedev as a hobby only 1-2 years ago (usually left projects unfinished, because scope creep, or I wasn't satisfied with them), currently playing around with Godot/Redot, but all the characters I worked so far were either frame-by-frame animations or skeletal based cutout characters. There is a plugin for l2d, but I have no idea what state that plugin is in.... (Unity definately has better support for l2d.)
If you are interested, I'll share the template demo as soon as its finished, then can take a look at l2d integration possibilities.
Btw, do you plan to monetize the game?
Regards,
Vol