Anna is a reporter covering news for events that take place in the city so the clue can be found by reading newspaper (Dream City Observer). If you read any events such as protests, fights or homicide cases, that means Anna has already been there at the location yesterday. Write the location on a piece of paper. Then load your saved game progress to go back in time. Hopefully your saved game progress is before the event takes place. If not, at least you have her location and can try again the next year.
Your objective is to improve her relationship to at least ally (21). Once you achieved that, she'll give a mission to investigate Jimmy, your predecessor & key to access safe house. Access to safe house is important milestone in the game because that gives you access to talk to Bobby and Priscilla which is very important character in later part of the game. However that part talking to Bobby & Priscilla not yet included in the game.
If you purchased DC Fugitive game, you play as Bobby & have the chance to meet the main character you're playing right now in DC Profitist game & Priscilla. Later we'll release DC Psyche game where you play as Priscilla. So all 3 games (DC Profitist, DC Fugitive and DC Psyche are connected to each other through these interaction.