Spot the difference is just clicking on the objects in each room that are different than their round 0 counterparts. For example, the dvd cases under the tv are colored so if they turn to just one color, then you gotta click on it. The same apply to the other objects in the apartment. The objects in round 0 don't change every time you play so you just gotta remember them and you're good for the whole game. Anomaly escape is just if you see an object that's different from round 0, then you click the change icon, and if not, click the next icon. Anomaly escape is just a more mindless version of spot the difference pretty much.
Are the required points for upgrades high? I get at least 10 points each run so I don't think it's too bad. Get more upgrades to help you get better, that's the point of them.