I’m on a Mac and had this same issue too, every RPG Maker game just stopped working when I updated to Sequoia. I managed to get it to work by following the instructions here (in Proxxie_Desu’s post):
https://forums.rpgmakerweb.com/index.php?threads/need-some-help-cannot-open-a-game-on-my-macbook-pro-the-game-was-made-from-the-rpg-maker-mv.150926/#post-1307030
